Hsp70 as an indicator of stress in the cells after contact with nanoparticles

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33156628" target="_blank" >RIV/61989592:15310/15:33156628 - isvavai.cz</a>
Result on the web
<a href="http://iopscience.iop.org/article/10.1088/1742-6596/617/1/012023/pdf" target="_blank" >http://iopscience.iop.org/article/10.1088/1742-6596/617/1/012023/pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1088/1742-6596/617/1/012023" target="_blank" >10.1088/1742-6596/617/1/012023</a>

Result language
angličtina
Original language name
Hsp70 as an indicator of stress in the cells after contact with nanoparticles
Original language description
Heat shock proteins (HSP) are among the substances that can be used for monitoring stress in cells. HSP are structures with a chaperone activity. They are evolutionarily very old, conservative and they are found with a high degree of homology in prokaryotes and eukaryotes including humans. They exist at low concentrations under physiological conditions, while in the denaturing conditions e.g. high or low temperature, radiation, exposure to chemicals, heavy metals, or nanoparticles their expression is changed. HSPs are involved in maintaining homeostasis in the cell that the denatured protein conformations allow recovery to the original stage. One of the most common proteins from HSP family is Hsp70 - protein with a molecular weight of 70 kDa. The levelof Hsp70 in a cell after exposure to the stress changes depending on the stress level to which the cell is exposed to and a time period during which lasted stressful conditions. Our research monitors stress levels of cells manifesting by
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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