Hsp90-a potential prognostic marker in CML
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10193353" target="_blank" >RIV/00216208:11310/13:10193353 - isvavai.cz</a>
Alternative codes found
RIV/00023736:_____/13:00010466
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S1079979612001982" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1079979612001982</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bcmd.2012.11.002" target="_blank" >10.1016/j.bcmd.2012.11.002</a>
Alternative languages
Result language
angličtina
Original language name
Hsp90-a potential prognostic marker in CML
Original language description
Heat shock proteins (Hsp) are important for the stability and function of cell proteins and thus for cell survival under physiological as well as stress conditions. Hsps were also reported to play an important role in tumorogenesis including leukemias. In this study we followed up Hsp70 and 90 protein levels in samples from patients with chronic myeloid leukemia (CML) to evaluate these Hsps with regard to their ability to characterize the disease status and disease prognosis. We analyzed 68 samples of total leukocytes of CML patients with different response to therapy with tyrosine kinase inhibitors. The results of Western blot analyses showed that the level of Hsp70 did not change in the course of the disease and did not correlate with response to therapy. In contrast, Hsp90 levels showed good correlation with the disease state. Patients with good response to therapy (major molecular response-MMR, molecular remission-CMR) had low expression levels of Hsp90, similar to those in healthy
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT12392" target="_blank" >NT12392: Heterogeneity of active-protein profiles in chronic myeloid leukemia and the disease prognosis</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Blood Cells, Molecules, and Diseases
ISSN
1079-9796
e-ISSN
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Volume of the periodical
50
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
184-189
UT code for WoS article
000315074500009
EID of the result in the Scopus database
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