Potential Clinical Uses of CDK Inhibitors: Lessons from Synthetic Lethality Screens

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33157602" target="_blank" >RIV/61989592:15310/15:33157602 - isvavai.cz</a>

Alternative codes found

RIV/61389030:_____/15:00450910

Result on the web

<a href="http://onlinelibrary.wiley.com/doi/10.1002/med.21354/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/med.21354/epdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/med.21354" target="_blank" >10.1002/med.21354</a>

Result language

angličtina

Original language name

Potential Clinical Uses of CDK Inhibitors: Lessons from Synthetic Lethality Screens

Original language description

Developments in genetic and genomic technology have produced vast quantities of data that are gradually yielding new insights into fundamental cellular and molecular processes. In particular, they have revealed some differences between normal and transformed cells that could potentially be exploited to develop targeted, personalized cancer therapies with unprecedented efficiencies. This review summarizes recent findings from synthetic lethality (SL) screens against cyclin-dependent kinases (CDKs) that can be targeted with small molecule kinase inhibitors. SL screens can be used to identify cancers sensitive to CDK inhibitors. Several SL partners of specific CDKs have been identified, including MYC, K-Ras, VHL, PI3K, and PARP, all of which are discussedin the review. CDK inhibitors have been in clinical trials for nearly 20 years and it has become clear that effective therapy using these compounds will require careful selection of patients with respect to the specific molecular phenoty

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Medicinal Research Reviews

ISSN

0198-6325

e-ISSN

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Volume of the periodical

35

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

19

Pages from-to

1156-1174

UT code for WoS article

000362795200003

EID of the result in the Scopus database

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