Electrochemical oxidation of zopiclone

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F16%3A33161001" target="_blank" >RIV/61989592:15310/16:33161001 - isvavai.cz</a>

Result on the web

<a href="http://link.springer.com/article/10.1007%2Fs00706-015-1602-9" target="_blank" >http://link.springer.com/article/10.1007%2Fs00706-015-1602-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00706-015-1602-9" target="_blank" >10.1007/s00706-015-1602-9</a>

Result language

angličtina

Original language name

Electrochemical oxidation of zopiclone

Original language description

Electrochemical behaviour of zopiclone was investigated on glassy carbon electrode in static and rotation disc arrangement. Strong influence of kinetics and adsorption phenomena on the electrode processes was proved by voltammetric techniques. Controlled potential electrolysis in off-line and on-line combination with tandem mass spectrometry was employed for investigation of the products of electrochemical oxidation. N-Desmethyl zopiclone was identified and three other oxidation products formed by an introduction of one or two oxygen atom(s) to the molecule of zopiclone (including zopiclone N-oxide) were characterized. Based on mass spectrometric investigation of those products, piperazine moiety was proved as a target of electrochemical oxidation of zopiclone. Since N-desmethyl zopiclone and zopiclone N-oxide have been reported as products of enzymatic metabolism of the drug, the combination of electrochemistry with mass spectrometry may be considered as a reliable tool for simulation of some metabolic transformations.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

<a href="/en/project/LO1305" target="_blank" >LO1305: Development of the center of advanced technologies and materials</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Monatshefte für Chemie

ISSN

0026-9247

e-ISSN

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Volume of the periodical

147

Issue of the periodical within the volume

1

Country of publishing house

AT - AUSTRIA

Number of pages

8

Pages from-to

53-60

UT code for WoS article

000367521400008

EID of the result in the Scopus database

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