Potentiation of mitochondrial dysfunction in tumor cells by conjugates of metabolic modulator dichloroacetate with a Pt(IV) derivative of oxaliplatin

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F16%3A33161184" target="_blank" >RIV/61989592:15310/16:33161184 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/16:00506413

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S0162013415301331" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0162013415301331</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jinorgbio.2015.12.003" target="_blank" >10.1016/j.jinorgbio.2015.12.003</a>

Result language

angličtina

Original language name

Potentiation of mitochondrial dysfunction in tumor cells by conjugates of metabolic modulator dichloroacetate with a Pt(IV) derivative of oxaliplatin

Original language description

Toxic effects of new antitumor Pt(IV) derivatives of oxaliplatin containing axial dichloroacetate ligands have been described. The results indicate that mechanism of biological action of these Pt(IV) prodrugs is different from that of conventional oxaliplatin and is connected with the effects on mitochondria, metabolism of glucose and that autophagy is implicated.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Inorganic Biochemistry

ISSN

0162-0134

e-ISSN

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Volume of the periodical

156

Issue of the periodical within the volume

MAR

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

89-97

UT code for WoS article

000370769400010

EID of the result in the Scopus database

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