Synthesis of modified D-mannose core derivatives and their impact on GH38 α-mannosidases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F16%3A33163371" target="_blank" >RIV/61989592:15310/16:33163371 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0008621516301008" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0008621516301008</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.carres.2016.04.004" target="_blank" >10.1016/j.carres.2016.04.004</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis of modified D-mannose core derivatives and their impact on GH38 α-mannosidases
Original language description
Nine new compounds having five- and modified six-member carbohydrate core derived from D-lyxose or D-mannose, and non-hydrolysable aglycones (benzylsulfonyl or aryl(alkyl)triazolyl) were synthesised to investigate their ability to inhibit the recombinant Drosophila melanogaster homologs of two human GH38 family enzymes: Golgi mannosidase II (dGMIIb) and lysosomal mannosidase (dLMII). Two compounds were weak selective dGMIIb inhibitors showing IC 50 at mM level. Moreover, it was found that another GH38 enzyme, commercial jack bean α-mannosidase, was inhibited by triazole conjugates regardless of the carbohydrate core while the corresponding sulfones were inactive.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/EE2.4.31.0130" target="_blank" >EE2.4.31.0130: Development and bolstering of cooperation among academic and commercial institutions with focuse on chemical and pharmaceutical research</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Carbohydrate Research
ISSN
0008-6215
e-ISSN
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Volume of the periodical
428
Issue of the periodical within the volume
JUN
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
"62-71"
UT code for WoS article
000376263000008
EID of the result in the Scopus database
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