Synthesis, structural characterization and cytotoxicity evaluation of platinum(II) complexes of heterocyclic selenones
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F17%3A73583700" target="_blank" >RIV/61989592:15310/17:73583700 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S027753871730147X" target="_blank" >https://www.sciencedirect.com/science/article/pii/S027753871730147X</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.poly.2017.02.027" target="_blank" >10.1016/j.poly.2017.02.027</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis, structural characterization and cytotoxicity evaluation of platinum(II) complexes of heterocyclic selenones
Original language description
Platinum(II) complexes (1-6) with selenones (HLn), having the general formula [Pt(HLn)(4)]Cl-2, were prepared and characterized by elemental analysis, IR and NMR (H-1, C-13, Se-77 and Pt-195) methods and one of them, [Pt(N-ethylimidazolidine-2-selenone)(4)]Cl-2 (3) by X-ray crystallography. A decrease in the IR frequency of the >C=Se mode and an upfield shift in C-13 NMR for the >C=Se resonance of selenones are consistent with the selenium coordination to platinum(II). The structure of 3 consists of [Pt(L3)(4)](2+) complex ion and chloride counter ions. The platinum(II) atom in complex cation adopts a distorted square planar geometry. The in vitro antitumor activity of the complexes, as well as cisplatin, were evaluated by MTT assay against human ovarian carcinoma A2780 and its cisplatin-resistant subline A2780R, human prostate cancer 22Rv1 and human breast adenocarcinoma MCF-7 cell lines. The results indicated that only one of the complexes, involving the N-propylimidazolidine-2-selenone (4) ligand, was effective against the A2780 cells (IC50 = 44.7 mu M) on the comparable level as cisplatin (IC50 = 26.8 mu M). The interaction studies with sulfur-containing biomolecules revealed their ability to form a variety of coordination and recombination intermediates, and oxidized species with L-cysteine and reduced glutathione.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
<a href="/en/project/LO1305" target="_blank" >LO1305: Development of the center of advanced technologies and materials</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Polyhedron
ISSN
0277-5387
e-ISSN
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Volume of the periodical
128
Issue of the periodical within the volume
MAY
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
2-8
UT code for WoS article
000401047100002
EID of the result in the Scopus database
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