Effects of selected triorganotin compounds on transcriptional activity of vitamin D3 receptor and peroxisome proliferator-activated receptor gamma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F18%3A73588465" target="_blank" >RIV/61989592:15310/18:73588465 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16370/18:43877070

Result on the web

<a href="http://dx.doi.org/10.4149/gpb_2018021" target="_blank" >http://dx.doi.org/10.4149/gpb_2018021</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/gpb_2018021" target="_blank" >10.4149/gpb_2018021</a>

Result language

angličtina

Original language name

Effects of selected triorganotin compounds on transcriptional activity of vitamin D3 receptor and peroxisome proliferator-activated receptor gamma

Original language description

Both, the vitamin D3 receptor (VDR) and the peroxisome proliferator-activated receptor gamma (PPARγ), are ligand-inducible transcription factors that control expressions of various genes involved in essential biological processes. Structurally diverse chemical substances are capable to bind to VDR and PPARγ, consequently acting in agonistic or antagonistic mode. Ubiquitous triorganotin compounds, key components of antifouling, disinfectant and biocidal agents were found to act as cognate ligands of several nuclear receptors. Triorganotins affect endocrine systems in disruptive manner recruiting proliferative, differentiation and apoptotic pathways. In this study, we have investigated agonistic as well as antagonistic effects of selected triorganotin compounds on VDR and PPARγ in transgenic gene reporter IZ-VDRE and PAZ-PPARγ human cell lines, allowing rapid and sensitive assessment of receptor transcriptional activity. We demonstrated that most of investigated triorganotins at nanomolar concentration exerted significant agonistic effects on VDR with fold activation ranging from 2.0 to 3.0-fold as well as some significant changes ranging from 127 to 199% of the maximal 1,25-dihydroxyvitamin D3 (calcitriol) induction, in antagonistic mode. In agonistic mode, PPARγ transcriptional activity was not affected by studied triorganotins significantly, but studied tributyltin compounds in antagonistic mode, revealed significant values ranging from 147 to 171% of the maximal 15-deoxy-δ12,14-prostaglandin J2 induction.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30108 - Toxicology

Project

<a href="/en/project/GA16-07544S" target="_blank" >GA16-07544S: Generation of high throughput in vitro models based on reporter gene assays for toxicological and environmental application</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

GENERAL PHYSIOLOGY AND BIOPHYSICS

ISSN

0231-5882

e-ISSN

—

Volume of the periodical

37

Issue of the periodical within the volume

5

Country of publishing house

SK - SLOVAKIA

Number of pages

8

Pages from-to

589-596

UT code for WoS article

000448096800010

EID of the result in the Scopus database

2-s2.0-85054780536