Canagliflozin-loaded magnetic nanoparticles as potential treatment of hypoxic tumors in combination with radiotherapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F18%3A73589739" target="_blank" >RIV/61989592:15310/18:73589739 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.2217/nnm-2018-0145" target="_blank" >http://dx.doi.org/10.2217/nnm-2018-0145</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2217/nnm-2018-0145" target="_blank" >10.2217/nnm-2018-0145</a>

Result language

angličtina

Original language name

Canagliflozin-loaded magnetic nanoparticles as potential treatment of hypoxic tumors in combination with radiotherapy

Original language description

Aim: To synthesize magnetic nanoparticles loaded with the SGLT2-inhibitor canagliflozin (CANA) and evaluate its anticancer potential under normoxic and hypoxic conditions in combination or not with radiotherapy. Material &amp; methods: Iron oxide nanoparticles were synthesized via an alkaline hydrolytic precipitation of iron precursor in the presence of poly(methacrylic acid)-graft-poly(ethyleneglycol methacrylate). CANA was conjugated to the nanoparticles using N-ethyl-N&apos;-(3-dimethyl aminopropyl) carbodiimide (EDC)/N-hydroxysuccinimide chemistry. The anticancer efficacy of the nanoparticles was evaluated in cancer cell lines and in a mouse PDV C57 tumor model. Results: In the mouse xenograft cancer model, the combination of CANA-loaded nanoparticles with radiotherapy (in the presence of an external magnetic field at the tumor site) exhibited higher antitumor activity compared with the combination of free CANA with radiotherapy. Conclusion: The results obtained indicate the potential that the combination of selective delivery of a SGLT2 inhibitor such as CANA with radiotherapy holds as an anticancer treatment.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10403 - Physical chemistry

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nanomedicine

ISSN

1743-5889

e-ISSN

—

Volume of the periodical

13

Issue of the periodical within the volume

19

Country of publishing house

GB - UNITED KINGDOM

Number of pages

20

Pages from-to

2435-2454

UT code for WoS article

000450853900005

EID of the result in the Scopus database

2-s2.0-85055906672