Combined antitumor effect of surface-modified superparamagnetic maghemite nanoparticles and a vitamin E derivative on experimental Walker-256 mammary gland carcinosarcoma

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F19%3A00494217" target="_blank" >RIV/61389013:_____/19:00494217 - isvavai.cz</a>
Alternative codes found
RIV/67985530:_____/19:00494217
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0304885318312216?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0304885318312216?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jmmm.2018.10.006" target="_blank" >10.1016/j.jmmm.2018.10.006</a>

Result language
angličtina
Original language name
Combined antitumor effect of surface-modified superparamagnetic maghemite nanoparticles and a vitamin E derivative on experimental Walker-256 mammary gland carcinosarcoma
Original language description
In a search for efficient anti-tumor agent, silica-coated superparamagnetic nanoparticles were designed and used in combination with vitamin E derivative as a potential new tool for anticancer treatment. The particles were characterized by numerous techniques, such as transmission electron microscopy and dynamic light scattering to determine the particle morphology and size both in dry state and water, atomic absorption spectroscopy to analyze the iron content, Fourier-transform infrared spectroscopy to confirm the presence of the functional groups, and vibrating sample magnetometry to determine the magnetic properties and content of maghemite. The next aim was to assess effect of the nanoparticles on suppression of experimental mammary gland carcinosarcoma W-256. Strong antitumor effect was achieved only with combined application of γ-Fe2O3@SiO2 and acetate derivative of α-tocopherol (Toc-6-Ac) resulting in 58% of tumor volume reduction. The results were compared with those obtained with poly(N,N-dimethylacrylamide)-coated iron oxide particles described earlier.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10404 - Polymer science

Project
<a href="/en/project/GA17-04918S" target="_blank" >GA17-04918S: Treating Glioblastoma with surface engineered superparamagnetic iron oxide nanoparticles for efficient conjugation with anticancer drugs</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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