Potentiation of cytotoxic action of cis-[PtCl2(NH3)(1M7AI)] by UVA irradiation. Mechanistic insights

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F18%3A73589825" target="_blank" >RIV/61989592:15310/18:73589825 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/18:00487346
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S002016931730645X" target="_blank" >https://www.sciencedirect.com/science/article/pii/S002016931730645X</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ica.2017.06.026" target="_blank" >10.1016/j.ica.2017.06.026</a>

Result language
angličtina
Original language name
Potentiation of cytotoxic action of cis-[PtCl2(NH3)(1M7AI)] by UVA irradiation. Mechanistic insights
Original language description
UVA irradiation can substantially potentiate the toxicity of a cisplatin derivative, cis-[PtCl2(NH3)(1-methyl-7-azaindole)], in tumor cells. The data provide convincing evidence that the replacement of the ammine in the molecule of cisplatin by the 1-methyl-7-azaindole ligand might lead to a new potential candidate for photoactivated chemotherapy (PACT) against some types of cancer.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10610 - Biophysics

Project
<a href="/en/project/LO1204" target="_blank" >LO1204: Sustainable development of research in the Centre of the Region Haná</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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