Effect of sulfonamidoethylenediamine substituents in Ru-II arene anticancer catalysts on transfer hydrogenation of coenzyme NAD( ) by formate
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F18%3A73589831" target="_blank" >RIV/61989592:15310/18:73589831 - isvavai.cz</a>
Result on the web
<a href="https://pubs.rsc.org/en/content/articlepdf/2018/dt/c8dt00438b" target="_blank" >https://pubs.rsc.org/en/content/articlepdf/2018/dt/c8dt00438b</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c8dt00438b" target="_blank" >10.1039/c8dt00438b</a>
Alternative languages
Result language
angličtina
Original language name
Effect of sulfonamidoethylenediamine substituents in Ru-II arene anticancer catalysts on transfer hydrogenation of coenzyme NAD( ) by formate
Original language description
A series of neutral pseudo-octahedral Ru-II sulfonamidoethylenediamine complexes [((6)-p-cym)Ru(N,N)Cl] where N,N is N-(2-(R-1,R-2-amino)ethyl)-4-toluenesulfonamide (TsEn(R-1,R-2)) R-1,R-2 = Me,H (1); Me,Me (2); Et,H (3); benzyl,H (Bz, 4); 4-fluorobenzyl,H (4-F-Bz, 5) or naphthalen-2-ylmethyl,H (Naph, 6), were synthesised and characterised. The complexes exhibited antiproliferative activity towards A2780 human ovarian cancer cells with IC50 values ranging from 1 to 31 uM, the most potent complex, [((6)-p-cym)Ru(TsEn(Bz,H))Cl], having a potency similar to the anticancer drug cisplatin.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
DALTON TRANSACTIONS
ISSN
1477-9226
e-ISSN
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Volume of the periodical
47
Issue of the periodical within the volume
21
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
7178-7189
UT code for WoS article
000433511700010
EID of the result in the Scopus database
2-s2.0-85047769430