Synthesis and characterization of (Ru(II), Co(III)) heterobimetallic complexes formed with a 1,10-phenanthroline based hydroxamic acid conjugate
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F20%3A00539536" target="_blank" >RIV/68081707:_____/20:00539536 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/20:73603655
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0022328X20301674?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0022328X20301674?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jorganchem.2020.121265" target="_blank" >10.1016/j.jorganchem.2020.121265</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis and characterization of (Ru(II), Co(III)) heterobimetallic complexes formed with a 1,10-phenanthroline based hydroxamic acid conjugate
Original language description
A novel ambidentate type hydroxamic acid derivative (phenhaH, 1) containing an (O,O) and a 1,10-phenantroline (phen) based (N,N) donoratom set together with its heterobimetallic complexes incorporating an octahedral [Co(4 N)](3+) (4 N = tris(2-aminoethyl)amine (tren) or tris(2-methylpyridyl)amine (tpa)) and a half-sandwich type [(eta(6)-p-cym)Ru](2+) entity have been synthesized and characterized using various analytical techniques. Reaction of [Co(4 N)Cl]Cl-2 with 1 proved the exclusive (O,O) coordination of the ligand to the [Co( 4 N)](3+) core to yield [Co(tpa)(phenha)](ClO4)(2), (2). Subsequent treatment of 1 with [Ru(eta(6)-p-cym)Cl-2](2) and [Co(4 N)Cl]Cl-2 in a one-pot reaction resulted in the formation of [(eta(6)-p-cym)Ru(Cl)(phenha)Co(tren)]Cl(PF6)(2) (3) and [(eta(6)-p-cym)Ru(Cl)(phenha)Co(tpa)](PF6)(3) (4) in which the organometallic Ru core is coordinated by the phen part while the Co entity by the hydroxamate part of 1. Cyclic voltammetry revealed that 4 could be reduced at a less negative potential and exhibits a reversible Co(III)/Co(II) redox process compared to 3 due to the pi-back bonding interaction between the Co(III) centre and the pyridyl-N donors of tpa in 4. Complexes 2-4 were tested for their in vitro cytotoxicity using human-derived cancer cell lines (HeLa, MCF-7, HCT116 and MDA-MB-231) and showed moderate anti-proliferative activity in the double digit micromolar concentration range, 4 being the most active. Complex 4 displayed better activity against MDA-MB-231 cells than cisplatin. (C) 2020 The Authors. Published by Elsevier B.V.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
<a href="/en/project/GA18-09502S" target="_blank" >GA18-09502S: Targeting resistance to chemotherapy of tumor cells to reinstate their susceptibility to novel, existing and unsuccessful anticancer metallodrugs</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Organometallic Chemistry
ISSN
0022-328X
e-ISSN
—
Volume of the periodical
916
Issue of the periodical within the volume
JUN 14 2020
Country of publishing house
CH - SWITZERLAND
Number of pages
9
Pages from-to
121265
UT code for WoS article
000537690200011
EID of the result in the Scopus database
2-s2.0-85082869532