Bipyrimidine ruthenium(II) arene complexes: structure, reactivity and cytotoxicity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F12%3A00383620" target="_blank" >RIV/68081707:_____/12:00383620 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s00775-012-0917-9" target="_blank" >http://dx.doi.org/10.1007/s00775-012-0917-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00775-012-0917-9" target="_blank" >10.1007/s00775-012-0917-9</a>

Result language
angličtina
Original language name
Bipyrimidine ruthenium(II) arene complexes: structure, reactivity and cytotoxicity
Original language description
We have studied and contrasted the chemical reactivity of a series of organometallic RuII complexes of the type [(?6-arene)Ru(N,N?)X][PF6] containing an N,N chelating ligand, as well as various arenes, and different halildes (X). Calf thymus DNA interactions for [(?6-p-cym)Ru(bpm)Cl][PF6] and [(?6-p-cym)Ru(phen)Cl][PF6] (cym=para cymene, bpm=2,2-bipyrimidine, phen=1,10-phenanthroline) consist of weak coordinative, intercalative and monofunctional coordination. Binding to biomolecules such as glutationemay play a role in deactivating the bpm complexes.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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