A half-sandwich Ta-V dichlorido complex containing an O,N,O '-tridentate Schiff base ligand: synthesis, crystal structure and in vitro cytotoxicity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F19%3A73596422" target="_blank" >RIV/61989592:15310/19:73596422 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/pdf/10.1107/S2053229619001323" target="_blank" >https://onlinelibrary.wiley.com/doi/pdf/10.1107/S2053229619001323</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1107/S2053229619001323" target="_blank" >10.1107/S2053229619001323</a>

Result language
angličtina
Original language name
A half-sandwich Ta-V dichlorido complex containing an O,N,O '-tridentate Schiff base ligand: synthesis, crystal structure and in vitro cytotoxicity
Original language description
A new electroneutral half-sandwich tantalum(V) dichlorido complex containing pentamethylcyclopentadienyl (Cp*) and the double-deprotonated version of the Schiff base 2-ethoxy-6-{(E)-[(2-hydroxyphenyl)imino]methyl}phenol (H2L) as ligands, namely cis-dichlorido(2-ethoxy-6-{(E)-[(2-oxidophenyl)imino]methyl}phenolato- kappa O-3,N,O')(eta(5)-pentamethylcyclopentadienyl)tantalum(V), [Ta(C10H15)(C15H13NO3)Cl-2] or [Ta(eta(5)-Cp*)(L)Cl-2], has been prepared and thoroughly characterized by elemental analysis, IR and NMR spectroscopy, mass spectrometry, density functional theory (DFT) calculations and single-crystal X-ray diffraction. The molecular structure revealed that the Ta-V centre is coordinated by a eta(5)-Cp* ligand, two monodentate chlorido ligands and one O,N,O'-tridentate L2- ligand. The crystal structure is stabilized by C-H center dot center dot center dot C, C-H center dot center dot center dot Cl and C center dot center dot center dot C intermolecular interactions. Moreover, the complex shows notable in vitro cytotoxicity against the A2780 human ovarian carcinoma cell line, with IC50 = 14.4 mu M, which is higher than that of the conventional platinum-based anticancer drug cisplatin (IC50 = 20.1 mu M).
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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