A cytotoxic tantalum(v) half-sandwich complex: a new challenge for metal-based anticancer agents

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F18%3A73591058" target="_blank" >RIV/61989592:15310/18:73591058 - isvavai.cz</a>
Result on the web
<a href="https://pubs.rsc.org/en/content/articlepdf/2018/cc/c8cc05223a" target="_blank" >https://pubs.rsc.org/en/content/articlepdf/2018/cc/c8cc05223a</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c8cc05223a" target="_blank" >10.1039/c8cc05223a</a>

Result language
angličtina
Original language name
A cytotoxic tantalum(v) half-sandwich complex: a new challenge for metal-based anticancer agents
Original language description
Despite the biological relevance of complexes of various transition metals, tantalum complexes have long been neglected by bioinorganic chemists. Herein, we demonstrate potential chemotherapeutic applicability of the [Ta((5)-Cp*)Cl-2(salaph)] (1) complex, containing deprotonated Schiff base 2-{(E)-[(2-hydroxyphenyl)imino]methyl}phenol (H(2)salaph), which shows strong cytotoxicity in cancer cells, related to the induction of apoptosis and apoptosis-related processes, but shows low cytotoxicity in healthy cells.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10402 - Inorganic and nuclear chemistry

Project
<a href="/en/project/LO1305" target="_blank" >LO1305: Development of the center of advanced technologies and materials</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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