Effect of the Schiff base complex diaqua-(N-salicylidene-L-glutamato) copper(II) monohydrate on human tumor cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F13%3A43895370" target="_blank" >RIV/60461373:22330/13:43895370 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0014299913006912" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0014299913006912</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejphar.2013.09.038" target="_blank" >10.1016/j.ejphar.2013.09.038</a>
Alternative languages
Result language
angličtina
Original language name
Effect of the Schiff base complex diaqua-(N-salicylidene-L-glutamato) copper(II) monohydrate on human tumor cells
Original language description
The aim of our study was to estimate cytostatic/cytotoxic activity of the copper(II) Schiff base complex of the composition [Cu(N-salicylidene-L-glutamato)(H2O)(2)]center dot H2O, further Cu(SG-L)H2O, against human colon carcinoma cell line HT-29, as well as to determine type of cell death and to find out the molecular mechanism of apoptosis induced by this complex. Two highest concentrations (50, 100 mu mol/l) of the complex showed a strong cytotoxic activity against human colon carcinoma cells HT-29 after 72 h of influence. Other concentrations had a cytostatic activity. Unchelated copper(II) ions and free ligands had no effect on the cell growth. Cu(SG-L)H2O preferentially reduced cancer cell viability compared to healthy cells (NIH-3T3). Cu(SG-L)H2O induced apoptosis of cells HT 29 at all concentrations used (1-100 mu mol/l) after 4811 of influence. Apoptosis was carried out by the mitochondrial pathway with active caspases 3 and 9. By the spin trapping technique combined with elec
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN
0014-2999
e-ISSN
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Volume of the periodical
721
Issue of the periodical within the volume
1-3
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
178-184
UT code for WoS article
000327541600024
EID of the result in the Scopus database
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