Dinuclear doubly bridged phenoxido copper(II) complexes as efficient anticancer agents
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F23%3A73617077" target="_blank" >RIV/61989592:15310/23:73617077 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15640/23:73617077
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0223523422008947?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0223523422008947?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejmech.2022.114992" target="_blank" >10.1016/j.ejmech.2022.114992</a>
Alternative languages
Result language
angličtina
Original language name
Dinuclear doubly bridged phenoxido copper(II) complexes as efficient anticancer agents
Original language description
Two cationic [Cu-2(L1-2)(2)](ClO4)(2) (1, 2), and four neutral doubly bridged-phenoxido-copper(II) complexes [Cu-2(L3-4)(2)] (3, 4) and [Cu-2(L5-6)(2)(H2O)center dot 2H(2)O (5, 6) as well as 1D polymeric catena-[Cu(L-7)] (7), where HL1-2 and H2L3-7 represent tripodal tetradentate pyridyl or aliphatic-amino groups based 2,4-disubstituted phenolates, were synthesized and thoroughly characterized by various spectroscopic methods and single crystal X-ray analysis. The molecular structures of the complexes exhibited diverse geometrical environments around the central Cu(II) atoms. The in vitro antiproliferative activity of the isolated complexes and selected parent free ligands were screened against some human cancer cell lines (A2780, A2780R, PC-3, 22Rv1, MCF-7). The most promising cytotoxicity against cancer cells were obtained for 1-6, while complex 6 was found as the best per-forming as compared to the reference drug cisplatin. The cytotoxicity study of complex 6 was therefore extended to wider variety of cancer cell lines (HOS, A549, PANC-1, CaCo2, HeLa) and results revealed its significant cytotoxicity on all investigated human cancer cells. The cell uptake study showed that cytotoxicity of 6 (3 mu M concentration and 24 h of incubation) against A2780 cells was almost independent from the intracellular levels of copper. The effect of complexes 4, 6 and 7 on cell cycle of A2780 cells indicates that the mechanism of action in these complexes is not only different from that of cisplatin but also different among them. Complex 7 was able to induce apoptosis in A2780 cells, while complexes 4 and 6 did not and on the other hand, they showed considerable effect on autophagy induction and there are some clues that these complexes were able to induce cuproptosis in A2780 cells.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
<a href="/en/project/EF16_019%2F0000754" target="_blank" >EF16_019/0000754: Nanotechnologies for Future</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN
0223-5234
e-ISSN
1768-3254
Volume of the periodical
246
Issue of the periodical within the volume
January
Country of publishing house
FR - FRANCE
Number of pages
13
Pages from-to
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UT code for WoS article
000902003000005
EID of the result in the Scopus database
2-s2.0-85144060026