Cytotoxic dimeric half-sandwich Ru(II), Os(II) and Ir(III) complexes containing the 4,4 '-biphenyl-based bridging ligands
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F20%3A73604491" target="_blank" >RIV/61989592:15310/20:73604491 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/full/10.1002/aoc.5785" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1002/aoc.5785</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/aoc.5785" target="_blank" >10.1002/aoc.5785</a>
Alternative languages
Result language
angličtina
Original language name
Cytotoxic dimeric half-sandwich Ru(II), Os(II) and Ir(III) complexes containing the 4,4 '-biphenyl-based bridging ligands
Original language description
A series of dinuclear half-sandwich Ru(II), Os(II) and Ir(III) complexes [Ru-2(mu-L-n)(eta(6)-pcym)(2)Cl-2](PF6)(2) (1, 4), [Os-2(mu-L-n)(eta(6)-pcym)(2)Cl-2](PF6)(2) (2, 5) and [Ir-2(mu-L-n)(eta(5)-Cp*)(2)Cl-2](PF6)(2) (3, 6), based on 4,4 '-biphenyl-based bridging Schiff base ligands N,N '-(biphenyl-4,4 '-diyldimethylidyne)bis-2-(pyridin-2-yl)methanamine (L-1; for 1-3) and N,N '-(biphenyl-4,4 '-diyldimethylidyne)bis-2-(pyridin-2-yl)ethanamine (L-2; for 4-6) is reported; pcym = 1-methyl-4-(propan-2-yl)benzene, Cp* = pentamethylcyclopentadienyl. The complexes were characterized by relevant analytical techniques (i.e. elemental analysis, FT-IR, NMR, ESI-MS), and their in vitro cytotoxicity was assessed at six cancerous and two non-cancerous (healthy) human cell lines. Overall, complexes 4-6, containing the L-2 bridging ligand, revealed higher cytotoxicity as compared with 1-3 and, thus, they were studied in greater detail. The best-performing complex 6 exceeded at least twice the in vitro cytotoxicity of cisplatin and showed high selectivity towards the cancer cells over the normal ones, including the primary culture of human hepatocytes. In contrast to cisplatin, complexes 4-6 did not induce the cell cycle modification of the treated A2780 human ovarian carcinoma cells (studied by flow cytometry and Western blot analysis). High levels of superoxide anion were induced by complexes 4-6 at the A2780 cells. The levels of activated forms of Caspase-3 and Caspase-8 at the A2780 cells treated by Ru(II) complex 4 were comparable with cisplatin, while complexes 5 and 6 had only a minor effect on activation of these caspases.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
APPLIED ORGANOMETALLIC CHEMISTRY
ISSN
0268-2605
e-ISSN
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Volume of the periodical
34
Issue of the periodical within the volume
9
Country of publishing house
GB - UNITED KINGDOM
Number of pages
15
Pages from-to
"e5785-1"-"e5785-15"
UT code for WoS article
000533991000001
EID of the result in the Scopus database
2-s2.0-85084990923