Unexpected solution behaviour of ester-functionalized half-sandwich Ru(II) and Ir(III) complexes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F21%3APU142121" target="_blank" >RIV/00216305:26620/21:PU142121 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/21:73609430
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2021/DT/D1DT00466B" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2021/DT/D1DT00466B</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d1dt00466b" target="_blank" >10.1039/d1dt00466b</a>
Alternative languages
Result language
angličtina
Original language name
Unexpected solution behaviour of ester-functionalized half-sandwich Ru(II) and Ir(III) complexes
Original language description
Complexes [Ru(eta(6)-pcym)(bpy(dca))Cl]PF6 (Ru-dca) and [Ir(eta(5)-Cp*)(bpy(dca))Cl]PF6 (Ir-dca) were developed as model compounds for the investigation of multi-targeted ester-functionalized half-sandwich ruthenium(ii) and iridium(iii) complexes; pcym = 1-methyl-4-(propan-2-yl)benzene (p-cymene), bpy(dca) = 2,2 '-bipyridine-4,4 '-diyldimethanediyl bis(dichloroacetate), Cp* = pentamethylcyclopentadienyl. Aiming to understand the in-solution behaviour of these first-in-class complexes containing the pyruvate dehydrogenase kinase inhibitor dichloroacetate (dca) as the terminal bioactive substituent, several experiments were performed under aqueous conditions for Ru-dca and Ir-dca, as well as for compounds [Ru(eta(6)-pcym)(bpy(OH))Cl]PF6 (Ru-OH) and [Ir(eta(5)-Cp*)(bpy(OH))Cl]PF6 (Ir-OH), and acetyl analogues [Ru(eta(6)-pcym)(bpy(ac))Cl]PF6 (Ru-ac) and [Ir(eta(5)-Cp*)(bpy(ac))Cl]PF6 (Ir-ac) bearing a different (biologically inactive) terminal substituent; bpy(OH) = 2,2 '-bipyridine-4,4 '-diyldimethanol, bpy(ac) = 2,2 '-bipyridine-4,4 '-diyldimethanediyl diacetate. The experiments were also conducted in the presence of porcine liver esterase (PLE). All the six complexes were characterized by relevant techniques (e.g., NMR and mass spectrometry), including a single-crystal X-ray analysis of complexes Ru-dca, Ru-ac, Ru-OH and Ir-OH. Although designed as model compounds, Ru-dca, Ir-dca, Ru-OH and Ir-OH were also screened for their antiproliferative activity in four human cancer cell lines (HCT116 colon carcinoma, MDA-MB-231 and MCF-7 breast adenocarcinomas, DU145 prostate carcinoma), where the tested complexes did not show any effect (IC50 > 100 mu M).
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Dalton Transactions
ISSN
1477-9226
e-ISSN
1477-9234
Volume of the periodical
50
Issue of the periodical within the volume
23
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
8017-8028
UT code for WoS article
000651841500001
EID of the result in the Scopus database
2-s2.0-85108000125