Half-Sandwich Ru(II) and Os(II) Bathophenanthroline Complexes Containing a Releasable Dichloroacetato Ligand
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F18%3A73591072" target="_blank" >RIV/61989592:15310/18:73591072 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/1420-3049/23/2/420/htm" target="_blank" >https://www.mdpi.com/1420-3049/23/2/420/htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/molecules23020420" target="_blank" >10.3390/molecules23020420</a>
Alternative languages
Result language
angličtina
Original language name
Half-Sandwich Ru(II) and Os(II) Bathophenanthroline Complexes Containing a Releasable Dichloroacetato Ligand
Original language description
We report on the preparation and thorough characterization of cytotoxic half-sandwich complexes [Ru(eta(6)-pcym)(bphen)(dca)]PF6 (Ru-dca) and [Os(eta(6)-pcym)(bphen)(dca)]PF6 (Os-dca) containing dichloroacetate(1-) (dca) as the releasable O-donor ligand bearing its own cytotoxicity; pcym = 1-methyl-4-(propan-2-yl) benzene (p-cymene), bphen = 4,7-diphenyl-1,10-phenanthroline (bathophenanthroline). Complexes Ru-dca and Os-dca hydrolyzed in the water-containing media, which led to the dca ligand release (supported by H-1 NMR and electrospray ionization mass spectra). Mass spectrometry studies revealed that complexes Ru-dca and Os-dca do not interact covalently with the model proteins cytochrome c and lysozyme. Both complexes exhibited slightly higher in vitro cytotoxicity (IC50 = 3.5 mu M for Ru-dca, and 2.6 mu M for Os-dca) against the A2780 human ovarian carcinoma cells than cisplatin (IC50 = 5.9 mu M), while their toxicity on the healthy human hepatocytes was found to be IC50 = 19.1 mu M for Ru-dca and IC50 = 19.7 mu M for Os-dca. Despite comparable cytotoxicity of complexes Ru-dca and Os-dca, both the complexes modified the cell cycle, mitochondrial membrane potential, and mitochondrial cytochrome c release by a different way, as revealed by flow cytometry experiments. The obtained results point out the different mechanisms of action between the complexes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
MOLECULES
ISSN
1420-3049
e-ISSN
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Volume of the periodical
23
Issue of the periodical within the volume
2
Country of publishing house
CH - SWITZERLAND
Number of pages
16
Pages from-to
"420-1"-"420-16"
UT code for WoS article
000426436300200
EID of the result in the Scopus database
2-s2.0-85042228130