Half-sandwich Os(ii) and Ru(ii) bathophenanthroline complexes: anticancer drug candidates with unusual potency and a cellular activity profile in highly invasive triple-negative breast cancer cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F18%3A73591858" target="_blank" >RIV/61989592:15310/18:73591858 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/18:00495085
Result on the web
<a href="https://pubs.rsc.org/en/content/articlepdf/2018/dt/c8dt02236d" target="_blank" >https://pubs.rsc.org/en/content/articlepdf/2018/dt/c8dt02236d</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c8dt02236d" target="_blank" >10.1039/c8dt02236d</a>
Alternative languages
Result language
angličtina
Original language name
Half-sandwich Os(ii) and Ru(ii) bathophenanthroline complexes: anticancer drug candidates with unusual potency and a cellular activity profile in highly invasive triple-negative breast cancer cells
Original language description
The effect of two, recently developed metal-based half-sandwich complexes [Os(η6-pcym)(bphen)(dca)]PF6 (Os-dca) and [Ru(η6-pcym)(bphen)(dca)]PF6 (Ru-dca) [pcym = 1-methyl-4-(propan-2-yl)benzene (p-cymene); bphen = 4,7-diphenyl-1,10-phenanthroline (bathophenanthroline); dca = dichloroacetate] on triple-negative breast cancer cells MDA-MB-231 is reported. The complexes display selective toxicity in several tumor cells (at submicromolar concentrations), and a prominent effect is observed against highly progressive triple negative breast cancer MDA-MB-231 cells for Os-dca.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
DALTON TRANSACTIONS
ISSN
1477-9226
e-ISSN
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Volume of the periodical
47
Issue of the periodical within the volume
35
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
12197-12208
UT code for WoS article
000444400200020
EID of the result in the Scopus database
2-s2.0-85053477740