Phospholipid-modified carbon fiber brush electrode for the detection of dopamine and 3,4-dihydroxyphenylacetic acid

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F19%3A73597894" target="_blank" >RIV/61989592:15310/19:73597894 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs00706-019-2371-7" target="_blank" >https://link.springer.com/article/10.1007%2Fs00706-019-2371-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00706-019-2371-7" target="_blank" >10.1007/s00706-019-2371-7</a>

Result language
angličtina
Original language name
Phospholipid-modified carbon fiber brush electrode for the detection of dopamine and 3,4-dihydroxyphenylacetic acid
Original language description
Different procedures for modification of carbon fiber brush electrode (CFBE) with phospholipids were investigated using cyclic voltammetry and electrochemical impedance spectroscopy. Simple immersion of the preanodized electrode into hexane solution of asolectin (a mixture of soybean phospholipids) followed by formation of the phospholipid layer in NaCl solution was the most effective procedure. Phospholipid layer-modified electrode (PL-CFBE) was applied to detect dopamine and its metabolite, 3,4 dihydroxyphenylacetic acid, using differential pulse and square-wave voltammetry in phosphate buffer solution of pH 6.5. Accumulation of dopamine, supported by electrostatic interactions between positively charged amino group and negatively charged phosphate moiety of the layer, enhanced sensitivity of PL-CFBE compared to bare CFBE. On the contrary, repulsive interaction between 3,4 dihydroxyphenylacetate anion and negatively charged phosphate moiety of the layer suppressed PL-CFBE sensitivity, measured as a slope of calibration dependence.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry

Project
<a href="/en/project/GA17-05387S" target="_blank" >GA17-05387S: New Approaches for Monitoring of Transport of Selected Xenobiotics across Biomimetic Membranes</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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