Determination of residual solvents in isobutylboronic acid: Masking derivatization improves stability of GC column
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F19%3A73598149" target="_blank" >RIV/61989592:15310/19:73598149 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/full/10.1002/jssc.201800968" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1002/jssc.201800968</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jssc.201800968" target="_blank" >10.1002/jssc.201800968</a>
Alternative languages
Result language
angličtina
Original language name
Determination of residual solvents in isobutylboronic acid: Masking derivatization improves stability of GC column
Original language description
Masking derivatization was introduced for the determination of residual solvents in samples containing a volatile reactive matrix component(s). Isobutylboronic acid, used in the last step of Bortezomib synthesis, represents a compound passing to the gas phase and deteriorating a chromatographic column during a headspace analysis. The masking derivatization with 1,8-diaminonaphthalene allowed a simple and straightforward conversion of isobutylboronic acid to a stable nonvolatile derivative and thus prevented gas chromatography column deterioration. The method was successfully validated according to the guidelines of International Committee for Harmonization (Q3C (R6) Guideline for Residual Solvents) and international pharmacopoeias (Ph. Eur., USP) and approved by Teva Czech Industries for routine application.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JOURNAL OF SEPARATION SCIENCE
ISSN
1615-9306
e-ISSN
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Volume of the periodical
42
Issue of the periodical within the volume
8
Country of publishing house
DE - GERMANY
Number of pages
5
Pages from-to
1629-1633
UT code for WoS article
000465118000016
EID of the result in the Scopus database
2-s2.0-85062502653