All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Deciphering the Peculiar Behavior of beta-Lapachone in Lipid Monolayers and Bilayers

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F19%3A73600630" target="_blank" >RIV/61989592:15310/19:73600630 - isvavai.cz</a>

  • Result on the web

    <a href="https://pubs.acs.org/doi/full/10.1021/acs.langmuir.9b02886" target="_blank" >https://pubs.acs.org/doi/full/10.1021/acs.langmuir.9b02886</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1021/acs.langmuir.9b02886" target="_blank" >10.1021/acs.langmuir.9b02886</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Deciphering the Peculiar Behavior of beta-Lapachone in Lipid Monolayers and Bilayers

  • Original language description

    beta-Lapachone (beta-Lap) is a promising anticancer drug whose applications have been limited so far because of its poor solubility and stability. Its encapsulation in liposomes has been proposed to overcome these issues. However, surface pressure measurements show that beta-Lap exhibits atypical interfacial behavior when mixed with lipids. Although the drug does not seem to be retained in lipid monolayers as deduced from the pi-A isotherms, small changes in compressibility moduli suggest that beta-Lap actually interacts with lipids, either disorganizing or rigidifying their monolayers. Thermal and structural analyses of lipid bilayers confirm the existence of beta-Lap/lipid interactions and show that the drug inserts between hydrophobic chains, close to the polar headgroup in DPPC bilayers and deeper in the acyl chains in POPC bilayers. Molecular dynamics simulations allow a comprehensive description of the drug position and orientation in DOPC and POPC bilayers in the presence or absence of cholesterol.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10403 - Physical chemistry

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    LANGMUIR

  • ISSN

    0743-7463

  • e-ISSN

  • Volume of the periodical

    35

  • Issue of the periodical within the volume

    45

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    13

  • Pages from-to

    14603-14615

  • UT code for WoS article

    000497262300023

  • EID of the result in the Scopus database

    2-s2.0-85074578219