Deciphering the Peculiar Behavior of beta-Lapachone in Lipid Monolayers and Bilayers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F19%3A73600630" target="_blank" >RIV/61989592:15310/19:73600630 - isvavai.cz</a>
Result on the web
<a href="https://pubs.acs.org/doi/full/10.1021/acs.langmuir.9b02886" target="_blank" >https://pubs.acs.org/doi/full/10.1021/acs.langmuir.9b02886</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.langmuir.9b02886" target="_blank" >10.1021/acs.langmuir.9b02886</a>
Alternative languages
Result language
angličtina
Original language name
Deciphering the Peculiar Behavior of beta-Lapachone in Lipid Monolayers and Bilayers
Original language description
beta-Lapachone (beta-Lap) is a promising anticancer drug whose applications have been limited so far because of its poor solubility and stability. Its encapsulation in liposomes has been proposed to overcome these issues. However, surface pressure measurements show that beta-Lap exhibits atypical interfacial behavior when mixed with lipids. Although the drug does not seem to be retained in lipid monolayers as deduced from the pi-A isotherms, small changes in compressibility moduli suggest that beta-Lap actually interacts with lipids, either disorganizing or rigidifying their monolayers. Thermal and structural analyses of lipid bilayers confirm the existence of beta-Lap/lipid interactions and show that the drug inserts between hydrophobic chains, close to the polar headgroup in DPPC bilayers and deeper in the acyl chains in POPC bilayers. Molecular dynamics simulations allow a comprehensive description of the drug position and orientation in DOPC and POPC bilayers in the presence or absence of cholesterol.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
LANGMUIR
ISSN
0743-7463
e-ISSN
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Volume of the periodical
35
Issue of the periodical within the volume
45
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
14603-14615
UT code for WoS article
000497262300023
EID of the result in the Scopus database
2-s2.0-85074578219