Rhizoferrin Glycosylation in Rhizopus microsporus

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F20%3A73604133" target="_blank" >RIV/61989592:15310/20:73604133 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/20:00531142 RIV/00216208:11130/20:10412707 RIV/00064203:_____/20:10412707 RIV/71009396:_____/20:N0000003
Result on the web
<a href="https://www.mdpi.com/2309-608X/6/2/89/htm" target="_blank" >https://www.mdpi.com/2309-608X/6/2/89/htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/jof6020089" target="_blank" >10.3390/jof6020089</a>

Result language
angličtina
Original language name
Rhizoferrin Glycosylation in Rhizopus microsporus
Original language description
Rhizopusspp. are the most common etiological agents of mucormycosis, causing over 90% mortality in disseminated infections. The diagnosis relies on histopathology, culture, and/or polymerase chain reaction. For the first time, the glycosylation of rhizoferrin (RHF) was described in aRhizopus microsporusclinical isolate by liquid chromatography and accurate tandem mass spectrometry. The fermentation broth lyophilizate contained 345.3 +/- 13.5, 1.2 +/- 0.03, and 0.03 +/- 0.002 mg/g of RHF, imido-RHF, and bis-imido-RHF, respectively. Despite a considerable RHF secretion rate, we did not obtain conclusive RHF detection from a patient with disseminated mucormycosis caused by the sameR. microsporusstrain. We hypothesize that parallel antimycotic therapy, RHF biotransformation, and metabolism compromised the analysis. On the other hand, the full profile of posaconazole metabolites was retrieved by our in house software CycloBranch.
Czech name
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Czech description
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Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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