Natural Biopolymeric Nanoformulations for Brain Drug Delivery
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F20%3A73604517" target="_blank" >RIV/61989592:15310/20:73604517 - isvavai.cz</a>
Result on the web
<a href="https://obd.upol.cz/id_publ/333184403" target="_blank" >https://obd.upol.cz/id_publ/333184403</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Natural Biopolymeric Nanoformulations for Brain Drug Delivery
Original language description
The blood-brain barrier (BBB) prevents the passage of many drugs that target the central nervous system (CNS). The BBB represents a structure with a complex cellular organization that separates the brain parenchyma from the systemic circulation. The BBB acts not only as a mechanical barrier but also as a metabolic barrier because of the presence of numerous enzymes that are able to inactivate xenobiotics potentially harmful to the CNS. On the other hand, many drugs, such as anti-infectious drugs, antineoplastics and a number of drugs for the treatment of neurological or psychiatric diseases, have to circumvent the BBB and reach their targets in the CNS. An application of nanoparticles as drug carriers can be considered as one of the possible strategies of drug delivery to the CNS. The application of nanomaterials as drug carriers have a number of advantages, especially targeted biodistribution and controlled release and thus, increased bioavailability and decreased toxicity. Currently, various polymer materials are preferred as nanocar-riers because of their compatibility, inertness, and biodegradability. This 132contribution is focused on nanoformulations of various classes of drugs, the site of action of which is in the CNS, that were prepared using polymers of natural origin and their semisynthetic modifications representing a class of biocompatible and biodegradable carriers ensuring better therapeutic efficiency and toxicity profile of drugs.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
<a href="/en/project/LO1305" target="_blank" >LO1305: Development of the center of advanced technologies and materials</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Nanocarriers for Brain Targeting
ISBN
978-0-429-46507-9
Number of pages of the result
74
Pages from-to
131-203
Number of pages of the book
511
Publisher name
Apple Academic Press
Place of publication
Oakville
UT code for WoS chapter
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