Antipsoriatic natural products
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F20%3A73604951" target="_blank" >RIV/61989592:15310/20:73604951 - isvavai.cz</a>
Result on the web
<a href="https://obd.upol.cz/id_publ/333184837" target="_blank" >https://obd.upol.cz/id_publ/333184837</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/bs.armc.2020.02.005" target="_blank" >10.1016/bs.armc.2020.02.005</a>
Alternative languages
Result language
angličtina
Original language name
Antipsoriatic natural products
Original language description
Psoriasis, a chronic inflammatory skin disease, is characterized by abnormal differentiation and hyperproliferation of epidermal keratinocytes, inflammatory infiltration and increased skin vascularization. Despite their clinical efficacy, the current antipsoriatic drugs have a poor safety profile as they are responsible for a wide range of side effects such as skin irritation, teratogenicity, hepatotoxicity, nephrotoxicity, myelosuppression and even disease rebound after cessation. Recent studies highlighted that natural products derived from plants and marine organisms contain scaffold structures that can be exploited for the development of novel antipsoriatic drugs. Pure constituents isolated from plants and marine sponges, belonging to different chemical classes: alkaloids, cyclopeptides, flavonoids, furanocoumarins, organic acid derivatives, polyphenols, sphingolipids and terpenoids, and their analogues have been investigated for their antipsoriatic activity in different experimental models. The chapter reviews natural products derived from plants and marine organisms and their analogues which, based on their bioactivities and virtual screening studies, appear to be potential candidates for the development of novel antipsoriatic drugs.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
<a href="/en/project/EF16_019%2F0000868" target="_blank" >EF16_019/0000868: Molecular, cellular and clinical approach to healthy ageing</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Annual Reports in Medicinal Chemistry
ISBN
978-0-12-821019-2
Number of pages of the result
29
Pages from-to
297-325
Number of pages of the book
515
Publisher name
Academic Press
Place of publication
London
UT code for WoS chapter
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