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Antipsoriatic natural products

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F20%3A73604951" target="_blank" >RIV/61989592:15310/20:73604951 - isvavai.cz</a>

  • Result on the web

    <a href="https://obd.upol.cz/id_publ/333184837" target="_blank" >https://obd.upol.cz/id_publ/333184837</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/bs.armc.2020.02.005" target="_blank" >10.1016/bs.armc.2020.02.005</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Antipsoriatic natural products

  • Original language description

    Psoriasis, a chronic inflammatory skin disease, is characterized by abnormal differentiation and hyperproliferation of epidermal keratinocytes, inflammatory infiltration and increased skin vascularization. Despite their clinical efficacy, the current antipsoriatic drugs have a poor safety profile as they are responsible for a wide range of side effects such as skin irritation, teratogenicity, hepatotoxicity, nephrotoxicity, myelosuppression and even disease rebound after cessation. Recent studies highlighted that natural products derived from plants and marine organisms contain scaffold structures that can be exploited for the development of novel antipsoriatic drugs. Pure constituents isolated from plants and marine sponges, belonging to different chemical classes: alkaloids, cyclopeptides, flavonoids, furanocoumarins, organic acid derivatives, polyphenols, sphingolipids and terpenoids, and their analogues have been investigated for their antipsoriatic activity in different experimental models. The chapter reviews natural products derived from plants and marine organisms and their analogues which, based on their bioactivities and virtual screening studies, appear to be potential candidates for the development of novel antipsoriatic drugs.

  • Czech name

  • Czech description

Classification

  • Type

    C - Chapter in a specialist book

  • CEP classification

  • OECD FORD branch

    30107 - Medicinal chemistry

Result continuities

  • Project

    <a href="/en/project/EF16_019%2F0000868" target="_blank" >EF16_019/0000868: Molecular, cellular and clinical approach to healthy ageing</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Book/collection name

    Annual Reports in Medicinal Chemistry

  • ISBN

    978-0-12-821019-2

  • Number of pages of the result

    29

  • Pages from-to

    297-325

  • Number of pages of the book

    515

  • Publisher name

    Academic Press

  • Place of publication

    London

  • UT code for WoS chapter