Anticancer Half-Sandwich Rhodium(III) Complexes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F21%3A73609424" target="_blank" >RIV/61989592:15310/21:73609424 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2304-6740/9/4/26/htm" target="_blank" >https://www.mdpi.com/2304-6740/9/4/26/htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/inorganics9040026" target="_blank" >10.3390/inorganics9040026</a>
Alternative languages
Result language
angličtina
Original language name
Anticancer Half-Sandwich Rhodium(III) Complexes
Original language description
Platinum-based anticancer drugs are most likely the most successful group of bioinorganic compounds. Their apparent disadvantages have led to the development of anticancer compounds of other noble metals, resulting in several ruthenium-based drugs which have entered clinical trials on oncological patients. Besides ruthenium, numerous rhodium complexes have been recently reported as highly potent antiproliferative agents against various human cancer cells, making them potential alternatives to Pt- and Ru-based metallodrugs. In this review, half-sandwich Rh(III) complexes are overviewed. Many representatives show higher in vitro potency than and different mechanisms of action (MoA) from the conventional anticancer metallodrugs (cisplatin in most cases) or clinically studied Ru drug candidates. Furthermore, some of the reviewed Rh(III) arenyl complexes are also anticancer in vivo. Pioneer anticancer organorhodium compounds as well as the recent advances in the field are discussed properly, and adequate attention is paid to their anticancer activity, solution behaviour and various processes connected with their MoA. In summary, this work summarizes the types of compounds and the most important biological results obtained in the field of anticancer half-sandwich Rh complexes.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Inorganics
ISSN
2304-6740
e-ISSN
—
Volume of the periodical
9
Issue of the periodical within the volume
4
Country of publishing house
CH - SWITZERLAND
Number of pages
24
Pages from-to
"26-1"-"26-24"
UT code for WoS article
000643058500001
EID of the result in the Scopus database
2-s2.0-85104626083