Alterations in hormonal signals spatially coordinate distinct responses to DNA double-strand breaks in Arabidopsis roots
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F21%3A73610774" target="_blank" >RIV/61989592:15310/21:73610774 - isvavai.cz</a>
Result on the web
<a href="https://www.science.org/doi/epdf/10.1126/sciadv.abg0993" target="_blank" >https://www.science.org/doi/epdf/10.1126/sciadv.abg0993</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/sciadv.abg0993" target="_blank" >10.1126/sciadv.abg0993</a>
Alternative languages
Result language
angličtina
Original language name
Alterations in hormonal signals spatially coordinate distinct responses to DNA double-strand breaks in Arabidopsis roots
Original language description
Plants have a high ability to cope with changing environments and grow continuously throughout life. However, the mechanisms by which plants strike a balance between stress response and organ growth remain elusive. Here, we found that DNA double-strand breaks enhance the accumulation of cytokinin hormones through the DNA damage signaling pathway in the Arabidopsis root tip. Our data showed that activation of cytokinin signaling suppresses the expression of some of the PIN-FORMED genes that encode efflux carriers of another hormone, auxin, thereby decreasing the auxin signals in the root tip and causing cell cycle arrest at G(2) phase and stem cell death. Elevated cytokinin signaling also promotes an early transition from cell division to endoreplication in the basal part of the root apex. We propose that plant hormones spatially coordinate differential DNA damage responses, thereby maintaining genome integrity and minimizing cell death to ensure continuous root growth.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Science Advances
ISSN
2375-2548
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
25
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
"eabg0993-1"-"eabg0993-16"
UT code for WoS article
000664958400032
EID of the result in the Scopus database
2-s2.0-85108030727