Controlled nucleation of crystallization process as an efficient tool to tune the properties of corticosteroid API
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F22%3A73612814" target="_blank" >RIV/61989592:15310/22:73612814 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15640/22:73612814
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0032591022002285" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0032591022002285</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.powtec.2022.117334" target="_blank" >10.1016/j.powtec.2022.117334</a>
Alternative languages
Result language
angličtina
Original language name
Controlled nucleation of crystallization process as an efficient tool to tune the properties of corticosteroid API
Original language description
Crystallization as one of the final steps in the industrial production of active pharmaceutical ingredients (APIs) significantly influences their physicochemical and rheological properties. Different crystallization procedures including antisolvent crystallization, seeding crystallization, crystallization with templates and sonocrystallization were utilized for the production of corticosteroid APIs-fluticasone propionate. The final crystalline APIs obtained by individual crystallization procedures were characterized by a wide range of characterization techniques. We show that nucleation is a critical step that significantly affects APIs' properties. Controlled nucleation thus represents an easy method for managing these properties. Well-designed nucleation yields to crystalline products, which does not necessitate any post-processing including, e.g., micronization. These findings can be widely applied to the production of API with targeted properties.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
POWDER TECHNOLOGY
ISSN
0032-5910
e-ISSN
1873-328X
Volume of the periodical
402
Issue of the periodical within the volume
APR
Country of publishing house
CH - SWITZERLAND
Number of pages
8
Pages from-to
"17334-1"-117334
UT code for WoS article
000793463500010
EID of the result in the Scopus database
2-s2.0-85128166241