The role of plants and plant secondary metabolites as selective nitric oxide synthase (NOS) inhibitors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F22%3A73616785" target="_blank" >RIV/61989592:15310/22:73616785 - isvavai.cz</a>
Result on the web
<a href="https://obd.upol.cz/id_publ/333196672" target="_blank" >https://obd.upol.cz/id_publ/333196672</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-12-818797-5.00007-8" target="_blank" >10.1016/B978-0-12-818797-5.00007-8</a>
Alternative languages
Result language
angličtina
Original language name
The role of plants and plant secondary metabolites as selective nitric oxide synthase (NOS) inhibitors
Original language description
Nitric oxide (NO), an endogenous important signaling molecule, is being placed inside the cell and also between cells of the plants, animals, and bacteria cells. It participates in almost all cellular and bodily functions; it has a significant role in homeostasis in the regulation of the central nervous system, gastrointestinal, respiratory, genital, and urinary systems such as micro- and macrovascularization, inhibition of platelet aggregation, and neurotransmission. However, the overproduction of NO is implicated in some diseases such as arthritis, asthma, cerebral ischemia, and Parkinson's diseases besides neurodegeneration. Therefore, to have a proper understanding of the molecular mechanisms on the induction of NO on these diseases, the interest in studying therapeutic nitric oxide synthase (NOS) inhibitors has increased. This chapter provides an overview of the main advances in design strategies, the mechanism of action at the molecular level, and the search for selective NOS inhibitors from plants and plant secondary metabolites.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/EF16_019%2F0000868" target="_blank" >EF16_019/0000868: Molecular, cellular and clinical approach to healthy ageing</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Nitric Oxide in Plant Biology
ISBN
978-0-12-818797-5
Number of pages of the result
42
Pages from-to
53-94
Number of pages of the book
812
Publisher name
Academic Press
Place of publication
London
UT code for WoS chapter
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