Inducible nitric oxide synthase: Good or bad?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F17%3A43876003" target="_blank" >RIV/62157124:16370/17:43876003 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/17:00099908 RIV/00159816:_____/17:00068027
Result on the web
<a href="http://dx.doi.org/10.1016/j.biopha.2017.06.036" target="_blank" >http://dx.doi.org/10.1016/j.biopha.2017.06.036</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.biopha.2017.06.036" target="_blank" >10.1016/j.biopha.2017.06.036</a>

Result language
angličtina
Original language name
Inducible nitric oxide synthase: Good or bad?
Original language description
Nitric oxide synthases (NOS) are a family of isoforms responsible for the synthesis of the potent dilator nitric oxide (NO). Expression of inducible NOS (iNOS) occurs in conditions of inflammation, and produces large amounts of NO. In pathological conditions iNOS is regarded as a harmful enzyme and is proposed to be a major contributor to diseases of the cardiovascular system such as atherosclerosis. In this review, we address the notion that iNOS is a detrimental enzyme in disease and discuss its potentially beneficial roles. Additionally, we describe other molecules associated with iNOS in diseases such as atherosclerosis, and current research on therapeutic inhibitors tested to reduced pathology associated with cardiovascular diseases (CVD).
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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