Comparative Study of Powder Carriers Physical and Structural Properties
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F22%3A73617319" target="_blank" >RIV/61989592:15310/22:73617319 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14160/22:00128706 RIV/61989100:27640/22:10250415
Result on the web
<a href="https://www.mdpi.com/1999-4923/14/4/818" target="_blank" >https://www.mdpi.com/1999-4923/14/4/818</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/pharmaceutics14040818" target="_blank" >10.3390/pharmaceutics14040818</a>
Alternative languages
Result language
angličtina
Original language name
Comparative Study of Powder Carriers Physical and Structural Properties
Original language description
High specific surface area (SSA), porous structure, and suitable technological characteristics (flow, compressibility) predetermine powder carriers to be used in pharmaceutical technology, especially in the formulation of liquisolid systems (LSS) and solid self-emulsifying delivery systems (s-SEDDS). Besides widely used microcrystalline cellulose, other promising materials include magnesium aluminometasilicates, mesoporous silicates, and silica aerogels. Clay minerals with laminar or fibrous internal structures also provide suitable properties for liquid drug incorporation. This work aimed at a comparison of 14 carriers' main properties. Cellulose derivatives, silica, silicates, and clay minerals were evaluated for flow properties, shear cell experiments, SSA, hygroscopicity, pH, particle size, and SEM. The most promising materials were magnesium aluminometasilicates, specifically Neusilin (R) US2, due to its proper flow, large SSA, etc. Innovative materials such as FujiSil (R) or Syloid (R) XDP 3050 were for their properties evaluated as suitable. The obtained data can help choose a suitable carrier for formulations where the liquid phase is incorporated into the solid dosage form. All measurements were conducted by the same methodology and under the same conditions, allowing a seamless comparison of property evaluation between carriers, for which available company or scientific sources do not qualify due to different measurements, conditions, instrumentation, etc.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmaceutics
ISSN
1999-4923
e-ISSN
—
Volume of the periodical
14
Issue of the periodical within the volume
4
Country of publishing house
CH - SWITZERLAND
Number of pages
18
Pages from-to
"818-1"-"818-18"
UT code for WoS article
000785406900001
EID of the result in the Scopus database
2-s2.0-85131597374