Ligands and agonists of the aryl hydrocarbon receptor AhR: Facts and myths
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F23%3A73619474" target="_blank" >RIV/61989592:15310/23:73619474 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0006295223002174" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0006295223002174</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bcp.2023.115626" target="_blank" >10.1016/j.bcp.2023.115626</a>
Alternative languages
Result language
angličtina
Original language name
Ligands and agonists of the aryl hydrocarbon receptor AhR: Facts and myths
Original language description
The aryl hydrocarbon receptor (AhR) belongs to the essential helix-loop-helix transcription factors family. This receptor has a central role in determining host physiology and a variety of pathophysiologies ranging from inflammation and metabolism to cancer. AhR is a ligand-driven receptor with intricate pharmacology of activation depending on the type and quantity of ligand present. Therefore, a better understanding of AhR ligands per se is critical to move the field forward. In this minireview, we clarify some facts and myths about AhR ligands and how further studies could shed light on the true nature of AhR activation by these ligands. The review covers select chemical classes and explores parameters that qualify them as true receptor ligands.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/GA23-04662S" target="_blank" >GA23-04662S: Dietary monoterpenoids as a novel class of aryl hydrocarbon receptor negative allosteric modulators in the therapy of colon cancer</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BIOCHEMICAL PHARMACOLOGY
ISSN
0006-2952
e-ISSN
1873-2968
Volume of the periodical
213
Issue of the periodical within the volume
JUL
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
"115626-1"-"115626-13"
UT code for WoS article
001014798200001
EID of the result in the Scopus database
2-s2.0-85160713254