Cannabis-derived products antagonize platinum drugs by altered cellular transport

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F23%3A73619493" target="_blank" >RIV/61989592:15310/23:73619493 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/23:73619493 RIV/61989592:15640/23:73619493 RIV/00027006:_____/23:10176152

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0753332223005917?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0753332223005917?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biopha.2023.114801" target="_blank" >10.1016/j.biopha.2023.114801</a>

Result language

angličtina

Original language name

Cannabis-derived products antagonize platinum drugs by altered cellular transport

Original language description

Cannabinoids, a class of compounds derived from Cannabis sativa L., have recently become more widely accessible for public consumption in the form of diverse cannabis products, in parallel with weakening the measures that so far restricted their availability. The US Food and Drug Administration has approved several cannabis-derived drugs for management of various diseases as well as chemotherapy-induced nausea and vomiting. Besides the attenuation of adverse effects of chemotherapy, numerous reports about cannabinoid-mediated anticancer effects further motivate cancer patients to support their therapy with such products. Here we present a set of preclinical data with human cell culture models, suggesting that cannabidiol and cannabis extracts may effectively counteract the anticancer effects of the clinically widely used standard-of-care platinum -based drugs. We show that even low concentrations of cannabinoids reduced the toxicity of cisplatin, oxaliplatin, and carboplatin, an effect which was accompanied by decreased platinum adduct formation and a set of commonly used molecular markers. Mechanistically, our results excluded the possibility that the observed enhanced survival of cancer cells was mediated transcriptionally. Instead, trace metal analyses strongly indicate an inhibitory impact of cannabinoids on intracellular platinum accumulation, thereby implicating changes in cellular transport and/or retention of these drugs as the likely cause of the observed biological effects. Our study raises the possibility that the desirable effect of counteracting adverse effects of chemotherapy might, at least for some cannabinoids, reflect impaired cellular availability, and consequently attenuation of the anticancer effects of platinum drugs.Data availability: All data supporting the conclusions are available in the article and supplementary files. Raw data are available upon request from the corresponding author.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10620 - Other biological topics

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BIOMEDICINE &amp; PHARMACOTHERAPY

ISSN

0753-3322

e-ISSN

1950-6007

Volume of the periodical

163

Issue of the periodical within the volume

July 2023

Country of publishing house

FR - FRANCE

Number of pages

11

Pages from-to

114801

UT code for WoS article

000990814000001

EID of the result in the Scopus database

2-s2.0-85154051822