A disposable electrochemical sensor based on single-walled carbon nanotubes for the determination of anticancer drug dasatinib
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F23%3A73621533" target="_blank" >RIV/61989592:15310/23:73621533 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007/s00706-023-03043-w" target="_blank" >https://link.springer.com/article/10.1007/s00706-023-03043-w</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00706-023-03043-w" target="_blank" >10.1007/s00706-023-03043-w</a>
Alternative languages
Result language
angličtina
Original language name
A disposable electrochemical sensor based on single-walled carbon nanotubes for the determination of anticancer drug dasatinib
Original language description
Dasatinib is an anticancer drug that treats acute lymphoblastic leukemia, chronic myelogenous leukemia, and prostate cancer with several side effects. In this research, we suggest nanoparticle-modified screen-printed electrodes (SPCEs) as disposable electrochemical sensors for fast quantification of dasatinib in pharmaceutical formulations. Carbon nanotubes, single-walled carbon nanotubes (SWCNT), graphene, and graphene oxide-modified SPCEs were characterized by scanning electron microscopy. The study also recommends SWCNT-modified SPCEs as the best-performing electrode for determining dasatinib, demonstrating an excellent boosting effect on the oxidation response of dasatinib. This was accomplished using the square-wave voltammetry method. After optimization of the pH condition, pH 5.0 Britton-Robinson buffer, SWCNT-modified SPCEs demonstrated 94% recovery with optimum electro-oxidation activity. The oxidation currents exhibited linear relation with dasatinib concentration in the 0.1-100 mu M. Based on the results, a limit of detection of 0.06 mu M was obtained in the standard solution. The SWCNT-modified SPCEs have been applied to analyze dasatinib in pharmaceutical tablet samples. The demonstrated performance beats all comparable standard analytical tools and presumably may be used for general drug quantitation in pharmaceutical tablets.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
MONATSHEFTE FUR CHEMIE
ISSN
0026-9247
e-ISSN
1434-4475
Volume of the periodical
154
Issue of the periodical within the volume
10
Country of publishing house
AT - AUSTRIA
Number of pages
9
Pages from-to
1061-1069
UT code for WoS article
000952840100001
EID of the result in the Scopus database
2-s2.0-85150217361