PROTACs of cyclin-dependent kinases

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F24%3A73626691" target="_blank" >RIV/61989592:15310/24:73626691 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/abs/pii/S0065774324000137" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0065774324000137</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/bs.armc.2024.10.003" target="_blank" >10.1016/bs.armc.2024.10.003</a>

Result language
angličtina
Original language name
PROTACs of cyclin-dependent kinases
Original language description
Cyclin-dependent kinases (CDKs) have emerged as important therapeutic targets, and a number of small molecular inhibitors acting as ATP competitors have been developed. Kinase degradation induced by proteolysis-targeting chimeras (PROTACs) provides new insights into the modulation of protein kinases, including CDKs, and represents a novel alternative approach that offers several advantages over conventional inhibitors. In the following chapters, we highlight some important features of the development of CDK PROTACs, including their efficacy and selectivity, as well as some unexpected observations.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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