Orchestra of ligand-activated transcription factors in the molecular symphony of SERPINE 1 / PAI-1 gene regulation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F25%3A73626966" target="_blank" >RIV/61989592:15310/25:73626966 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0300908424002207" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0300908424002207</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.biochi.2024.09.010" target="_blank" >10.1016/j.biochi.2024.09.010</a>
Alternative languages
Result language
angličtina
Original language name
Orchestra of ligand-activated transcription factors in the molecular symphony of SERPINE 1 / PAI-1 gene regulation
Original language description
Plasminogen activator inhibitor 1 (PAI-1) is a crucial serine protease inhibitor that prevents plasminogen activation by inhibiting tissue- and urokinase-type plasminogen activators (tPA, uPA). PAI-1 is well-known for its role in modulating hemocoagulation or extracellular matrix formation by inhibiting plasmin or matrix metalloproteinases, respectively. PAI-1 is induced by pro-inflammatory cytokines across various tissues, yet its regulation by ligand-activated transcription factors is partly disregarded. Therefore, we have attempted to summarize the current knowledge on the transcriptional regulation of PAI-1 expression by the most relevant xenobiotic and endocrine receptors implicated in modulating PAI-1 levels. This review aims to contribute to the understanding of the specific, often tissue-dependent regulation of PAI-1 and provide insights into the modulation of PAI-1 levels beyond its direct inhibition.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/GA23-04662S" target="_blank" >GA23-04662S: Dietary monoterpenoids as a novel class of aryl hydrocarbon receptor negative allosteric modulators in the therapy of colon cancer</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BIOCHIMIE
ISSN
0300-9084
e-ISSN
1638-6183
Volume of the periodical
228
Issue of the periodical within the volume
JAN
Country of publishing house
FR - FRANCE
Number of pages
20
Pages from-to
138-157
UT code for WoS article
001421066300001
EID of the result in the Scopus database
2-s2.0-85205148762