Solid-phase synthesis of aryl squaramides using Liebeskind–Srogl cross-coupling

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F25%3A73632362" target="_blank" >RIV/61989592:15310/25:73632362 - isvavai.cz</a>
Result on the web
<a href="https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra02225h" target="_blank" >https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra02225h</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/D5RA02225H" target="_blank" >10.1039/D5RA02225H</a>

Result language
angličtina
Original language name
Solid-phase synthesis of aryl squaramides using Liebeskind–Srogl cross-coupling
Original language description
We present a method for the synthesis of aryl-substituted squaramides through the Liebeskind-Srogl cross-coupling reaction performed on solid support. This approach offers a unique application of cross-coupling reaction, allowing for the rapid and efficient production of a diverse range of substituted analogs within a combinatorial framework. Through our technique, we successfully synthesized derivatives that were previously unattainable. Additionally, the optimized conditions have been effectively applied in a scale-up reaction. The derivatives show potential for the treatment of drug-resistant tuberculosis.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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