Molecularly imprinted polymers for the detection of viruses: challenges and opportunities

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15640%2F21%3A73607538" target="_blank" >RIV/61989592:15640/21:73607538 - isvavai.cz</a>

Result on the web

<a href="https://pubs.rsc.org/en/content/articlelanding/2021/AN/D1AN00149C" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2021/AN/D1AN00149C</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/d1an00149c" target="_blank" >10.1039/d1an00149c</a>

Result language

angličtina

Original language name

Molecularly imprinted polymers for the detection of viruses: challenges and opportunities

Original language description

Molecularly imprinted polymers (MIPs) have numerous applications in the sensing field, the detection/recognition of virus, the structure determination of proteins, drug delivery, artificial/biomimetic antibodies, drug discovery, and cell culturing. There are lots of conventional methods routinely deployed for the analysis/detection of viral infections and pathogenic viruses, namely enzyme immunoassays, immunofluorescence microscopy, polymerase chain reaction (PCR) and virus isolation. However, they typically suffer from higher costs, low selectivity/specificity, false negative/positive results, time consuming procedures, and inherent labor intensiveness. MIPs offer promising potential for viral recognition/detection with high target selectivity, sensitivity, robustness, reusability, and reproducible fabrication. In terms of virus detection, selectivity and sensitivity are critical parameters determined by the template; additionally, the analytical detection and evaluation of viruses must have considerably low detection limits. The virus-imprinted polymer-based innovative strategies with enough specificity, convenience, validity, and reusability features for the detection/recognition of a wide variety of viruses, can provide attractive capabilities for reliable screening with minimal false negative/positive results that is so crucial for the prevention and control of epidemic and pandemic viral infections. However, in the process of imprinting viruses, critical factors such as size of the target, solubility, fragility, and compositional complexity should be analytically considered and systematically evaluated. In this review, recent advancements regarding the applications of MIPs and pertinent virus imprinting techniques for the detection of viruses, as well as their current significant challenges and future perspectives, are deliberated.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

21001 - Nano-materials (production and properties)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ANALYST

ISSN

0003-2654

e-ISSN

—

Volume of the periodical

2021

Issue of the periodical within the volume

146

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

3087-3100

UT code for WoS article

000637389600001

EID of the result in the Scopus database

2-s2.0-85106186868