Liposomes: Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15640%2F21%3A73612320" target="_blank" >RIV/61989592:15640/21:73612320 - isvavai.cz</a>

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fbioe.2021.705886/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fbioe.2021.705886/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fbioe.2021.705886" target="_blank" >10.3389/fbioe.2021.705886</a>

Result language

angličtina

Original language name

Liposomes: Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol

Original language description

Liposomes are essentially a subtype of nanoparticles comprising a hydrophobic tail and a hydrophilic head constituting a phospholipid membrane. The spherical or multilayered spherical structures of liposomes are highly rich in lipid contents with numerous criteria for their classification, including structural features, structural parameters, and size, synthesis methods, preparation, and drug loading. Despite various liposomal applications, such as drug, vaccine/gene delivery, biosensors fabrication, diagnosis, and food products applications, their use encounters many limitations due to physico-chemical instability as their stability is vigorously affected by the constituting ingredients wherein cholesterol performs a vital role in the stability of the liposomal membrane. It has well established that cholesterol exerts its impact by controlling fluidity, permeability, membrane strength, elasticity and stiffness, transition temperature (Tm), drug retention, phospholipid packing, and plasma stability. Although the undetermined optimum amount of cholesterol for preparing a stable and controlled release vehicle has been the downside, but researchers are still focused on cholesterol as a promising material for the stability of liposomes necessitating explanation for the stability promotion of liposomes. Herein, the prior art pertaining to the liposomal appliances, especially for drug delivery in cancer therapy, and their stability emphasizing the roles of cholesterol.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

21001 - Nano-materials (production and properties)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Bioengineering and Biotechnology

ISSN

2296-4185

e-ISSN

—

Volume of the periodical

9

Issue of the periodical within the volume

SEP

Country of publishing house

CH - SWITZERLAND

Number of pages

23

Pages from-to

"nečíslováno"

UT code for WoS article

000722866300001

EID of the result in the Scopus database

2-s2.0-85115653337