Preparation and Hydro-Lipophilic Properties of Novel Fluorinated Benzyl Carbamates of 4-Aminosalicylanilides
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15640%2F21%3A73612539" target="_blank" >RIV/61989592:15640/21:73612539 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2673-4583/3/1/32" target="_blank" >https://www.mdpi.com/2673-4583/3/1/32</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ecsoc-24-08094" target="_blank" >10.3390/ecsoc-24-08094</a>
Alternative languages
Result language
angličtina
Original language name
Preparation and Hydro-Lipophilic Properties of Novel Fluorinated Benzyl Carbamates of 4-Aminosalicylanilides
Original language description
A series of seven fluorinated benzyl carbamates of 4-aminosalicylanilides and unsubstituted benzyl [3-hydroxy-4-(phenylcarbamoyl)phenyl]carbamate designed as agents with the expected anticholinesterase and anti-inflammatory activity were prepared and characterized. As lipophilicity significantly influences the biological activity of compounds, the hydro-lipophilic properties of these mono-, di-, and tri-substituted carbamates were investigated in this study. All the discussed derivatives of 4-{[(benzyloxy)carbonyl]amino}-2-hydroxybenzoic acid were analyzed using reversed-phase high performance liquid chromatography to measure lipophilicity. The procedure was performed under isocratic conditions with methanol as an organic modifier in the mobile phase using an end-capped non-polar C18 stationary reversed-phase column. In the present study, the correlations between the logarithm of the capacity factor k, the logarithm of the distributive parameter D at pH 7.4, and log P/Clog P values calculated in various ways as well as the relationships between the lipophilicity and the chemical structure of the studied compounds are discussed.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
21001 - Nano-materials (production and properties)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Chemistry porceeding
ISBN
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ISSN
2673-4583
e-ISSN
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Number of pages
11
Pages from-to
"nečíslováno"
Publisher name
MDPI AG
Place of publication
Basel
Event location
online
Event date
Nov 15, 2020
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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