Rhodanineacetic Acid Derivatives as Potential Drugs: Preparation and Hydrophobic Properties of 5-Arylalkylidene-3-carboxymethylrhodanines
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F08%3A00002059" target="_blank" >RIV/62157124:16370/08:00002059 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Rhodanineacetic Acid Derivatives as Potential Drugs: Preparation and Hydrophobic Properties of 5-Arylalkylidene-3-carboxymethylrhodanines
Original language description
Some (5-arylalkylidene-4-oxo-2-thioxothiazolidin-3-yl)acetic acids were prepared as potential antimicrobial compounds. General synthetic approach of all synthesized compounds is presented. All the discussed rhodanine-3-acetic acid derivatives were analyzed using the reversed phase high performance liquid chromatography (RP-HPLC) method for the lipophilicity measurement. The procedure was performed under isocratic conditions with methanol as an organic modifier in the mobile phase using end-capped non-polar C18 stationary RP column. RP-HPLC retention parameter log k (the logarithm of capacity factor k) is compared with log P values calculated in silico. The relationships between the lipophilicity and chemical structure of the studied compounds are discussed as well.
Czech name
Příprava a hydrofobní vlastnosti 5-aralkyliden-3-karboxymethyrhodaninů
Czech description
Byla připravena série (5-arylalkyliden-4-oxo-2-thioxothiazolidin-3-yl)octových kyselin jako potenciální antimikrobní látky a byla u nich zhodnocena lipofilita pomocí RP-HPLC, vyjádřená kapacitním faktorem log k, který byl srovnáván s vypočtenými hodnotami log P.
Classification
Type
D - Article in proceedings
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
proceedings of 12th International Electronic Conference on Synthetic Organic Chemistry
ISBN
3-906980-20-0
ISSN
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e-ISSN
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Number of pages
1
Pages from-to
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Publisher name
Molecular Diversity Preservation International (MDPI)
Place of publication
Basel
Event location
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Event date
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Type of event by nationality
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UT code for WoS article
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