RP-HPLC lipophilicity determination of bispyridinium reactivators of acetylcholinesterase bearing a but-2-ene connecting linker

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F08%3A00002001" target="_blank" >RIV/60162694:G44__/08:00002001 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/08:00109199

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

RP-HPLC lipophilicity determination of bispyridinium reactivators of acetylcholinesterase bearing a but-2-ene connecting linker

Original language description

New acetylcholinesterase reactivators with either a (E) or (Z)-but-2-ene connecting linker were recently prepared. The purity of the compounds was checked by HPLC and was found to be sufficient for in-vitro screening. All the discussed bispyridinium reactivators were analyzed by reversed-phase high performance liquid chromatography (RP-HPLC) to measure lipophilicity. The procedure was performed under isocratic conditions with methanol as organic modifier in the mobile phase using an end-capped non-polarC18 stationary phase RP column. Relationships between the lipophilicity (logarithmof the RP-HPLC capacity factor, log k) and chemical structures of the studied compounds are discussed. Lipophilicity was different for the (E) and (Z) compounds and variedamong the compounds in each of these groups. The lipophilicity differences also indicated an apparent influence of intramolecular interactions. Lipophilicity calculations (log P/Clog P) by means of commonly used software were not success

Czech name

RP-HPLC určení lipofility bispyridiniových reaktivátorů acetylcholinesterasy nesoucích but-2-enový spojovací řetězec

Czech description

Dvanáct bispyridiniových sloučenin nesoucích (E)-but-2-enový nebo (Z)-but-2-enový spojovací řetězec bylo testováno pomocí RP-HPLC metodiky na čistotu a lipofilitu. Byly nalezeny důležité intramolekulární interakce.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

<a href="/en/project/GP305%2F07%2FP162" target="_blank" >GP305/07/P162: Relationship between structure of acetylcholinesterase reactivators and their reactivation potency</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Analytical and Bioanalytical Chemistry

ISSN

1618-2642

e-ISSN

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Volume of the periodical

391

Issue of the periodical within the volume

1

Country of publishing house

DE - GERMANY

Number of pages

6

Pages from-to

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UT code for WoS article

000255185300035

EID of the result in the Scopus database

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