Precision Fishing for Enzyme-like Materials: Identifying and Engineering Mesoporous Catalytic Sites for Ferroptosis Induction

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15640%2F25%3A73631477" target="_blank" >RIV/61989592:15640/25:73631477 - isvavai.cz</a>
Alternative codes found
RIV/61989100:27640/25:10258849
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acs.nanolett.5c02476" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.nanolett.5c02476</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.nanolett.5c02476" target="_blank" >10.1021/acs.nanolett.5c02476</a>

Result language
angličtina
Original language name
Precision Fishing for Enzyme-like Materials: Identifying and Engineering Mesoporous Catalytic Sites for Ferroptosis Induction
Original language description
The discovery of nanomaterials with enzyme-like activities, termed nanozymes, holds the potential to revolutionize traditional inhibitor-based therapies. However, precise identification of nanozymes for specific substrates and uncovering their catalytic domains remain significant challenges. Here, we developed a "fishing" method that utilizes AFM probes coated with substrate baits, functioning as fishing rods to enable in situ visualization of enzymatic reactions on nanomaterial surfaces. Through this approach, we identified four nanozymes, including graphene oxides (GOs) exhibiting lipoxygenase (LOX)-like activity. Notably, mesopores were identified as key catalytic domains on GO surfaces, guiding the engineering of tailored porous GOs (tp-GOs) with enhanced LOX-like activity. The optimized tp-GOs catalyzed ferroptosis in cancer cells and suppressed hepatic tumor growth and metastasis in mice. Our findings open new avenues in drug discovery, shifting the paradigm from enzyme inhibition to promoting specific biochemical reactions using nanozymes.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
21001 - Nano-materials (production and properties)

Project
<a href="/en/project/EH22_008%2F0004587" target="_blank" >EH22_008/0004587: Technology Beyond Nanoscale</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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