A Modular, Lego-Like Microfluidic Platform for Multimodal Analysis of Biofilm Formation and Antimicrobial Response
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15640%2F25%3A73632273" target="_blank" >RIV/61989592:15640/25:73632273 - isvavai.cz</a>
Result on the web
<a href="https://advanced.onlinelibrary.wiley.com/doi/10.1002/admi.202500303" target="_blank" >https://advanced.onlinelibrary.wiley.com/doi/10.1002/admi.202500303</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/admi.202500303" target="_blank" >10.1002/admi.202500303</a>
Alternative languages
Result language
angličtina
Original language name
A Modular, Lego-Like Microfluidic Platform for Multimodal Analysis of Biofilm Formation and Antimicrobial Response
Original language description
Biofilms are substantially more resistant compared to free-floating bacteria, highlighting the need for tools capable of real-time analysis under physiologically relevant conditions. A modular microfluidic platform with integrated electrodes is presented for dynamic sampling and monitoring of biofilm formation and response. Its architecture enables natural shear stress variations and allows label-free studies, including optical microscopy and electrical impedance spectroscopy. The platform evaluates biofilm growth, migration, and regrowth and investigates the effect of i) treatment using antibiotics and ii) antimicrobial coatings (i.e., silver nanoparticles) on Pseudomonas aeruginosa biofilms, revealing distinct stages of response and persistence in each case. Distinct biofilm behaviors are identified in response to antibiotic treatment as well as after applying an antibacterial coating (i.e., incomplete vs no biofilm eradication). Furthermore, the platform's modularity allows for biofilm migration and regrowth studies via Lego-like connected modules, emphasizing the need for strategies addressing biofilm resilience and regrowth. The system provides a robust, scalable, and biologically relevant alternative to traditional methods for biofilm research. In addition to basic assays, this system is well-suited for clinical environments, where timely and personalized therapeutic decisions are critical for managing biofilm-related infections.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10611 - Plant sciences, botany
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advanced Materials Interfaces
ISSN
2196-7350
e-ISSN
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Volume of the periodical
12
Issue of the periodical within the volume
20
Country of publishing house
DE - GERMANY
Number of pages
12
Pages from-to
nestránkováno
UT code for WoS article
001560179700001
EID of the result in the Scopus database
2-s2.0-105014598629