Common variable immunodeficiency patients display elevated plasma levels of granulocyte activation markers elastase and myeloperoxidase
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43110%2F19%3A43915469" target="_blank" >RIV/62156489:43110/19:43915469 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/19:00071198 RIV/00216224:14110/19:00108463
Result on the web
<a href="https://doi.org/10.1177/2058738419843381" target="_blank" >https://doi.org/10.1177/2058738419843381</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1177/2058738419843381" target="_blank" >10.1177/2058738419843381</a>
Alternative languages
Result language
angličtina
Original language name
Common variable immunodeficiency patients display elevated plasma levels of granulocyte activation markers elastase and myeloperoxidase
Original language description
Common variable immunodeficiency disorders (CVIDs) represent a group of primary immunodeficiency diseases characterized by hypogammaglobulinemia and dysfunctional immune response to invading pathogens. Previous studies have indicated that CVID is associated with microbial translocation and systemic myeloid cell activation. The goal of this study was to determine whether patients with CVID display elevated systemic levels of markers of granulocyte activation and whether the levels are further influenced by intravenous immunoglobulin (IVIg) infusions. The plasma levels of granulocyte activation markers elastase and myeloperoxidase were determined using enzyme-linked immunosorbent assay (ELISA) in 46 CVID patients and 44 healthy controls. All CVID patients were in a stable state with no apparent acute infection. In addition, granulocyte activation markers' plasma levels in 24 CVID patients were determined prior to and 1 h following IVIg administration. Neutrophil elastase and myeloperoxidase plasma levels were significantly higher in CVID patients than in healthy controls. Systemic elastase levels were further increased following IVIg administration. In vitro stimulation of 13 CVID patients' whole blood using IVIg in a therapeutically relevant dose for 2 h resulted in a significant increase in plasma elastase levels compared to unstimulated blood. The data presented here indicate that CVID is associated with chronic granulocytic activation which is further exacerbated by administering IVIg. Increased myeloperoxidase and elastase levels may contribute to associated comorbidities in CVID patients.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
<a href="/en/project/NV15-28732A" target="_blank" >NV15-28732A: Role of granulocytes and monocytes in induction and development of immunodeficiency disease and other immunopathological processes</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Immunopathology and Pharmacology
ISSN
0394-6320
e-ISSN
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Volume of the periodical
33
Issue of the periodical within the volume
10 April
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
"Nestrankovano"
UT code for WoS article
000464236600001
EID of the result in the Scopus database
2-s2.0-85064721431