Capillary Zone Electrophoretic Studies of Interactions of Some Quaternary Isoquinoline Alkaloids with DNA Constituents and DNA

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F05%3A00000799" target="_blank" >RIV/62156489:43210/05:00000799 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/05:00001999

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Capillary Zone Electrophoretic Studies of Interactions of Some Quaternary Isoquinoline Alkaloids with DNA Constituents and DNA

Original language description

Capillary zone electrophoresis was applied for the investigation of interactions of some quaternary isoquinoline alkaloids, namely sanguinarine, chelerythrine, berberine and jatrorrhizine, with DNA constituents and with DNA. None of these alkaloids attach covalently to nucleotides or to the whole DNA at physiological conditions. The interaction with DNA constituents is a non-covalent complexation based on weak intermolecular forces. Electrostatic attraction participates in the interaction but other types of intermolecular forces are involved as well. Cations were identified as the interacting forms of the alkaloids. The interaction with compounds derived from purine was always stronger that with those derived from pyrimidine. All alkaloids behaved analogously and similarly to ethidium bromide, the classic DNA intercalator.

Czech name

CZE studium interakcí některých kvarterních isochinolinových alkaloidů s DNA a DNA constituenty.

Czech description

Capillary zone electrophoresis was applied for the investigation of interactions of some quaternary isoquinoline alkaloids, namely sanguinarine, chelerythrine, berberine and jatrorrhizine, with DNA constituents and with DNA. None of these alkaloids attach covalently to nucleotides or to the whole DNA at physiological conditions. The interaction with DNA constituents is a non-covalent complexation based on weak intermolecular forces. Electrostatic attraction participates in the interaction but other types of intermolecular forces are involved as well. Cations were identified as the interacting forms of the alkaloids. The interaction with compounds derived from purine was always stronger that with those derived from pyrimidine. All alkaloids behaved analogously and similarly to ethidium bromide, the classic DNA intercalator.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Electrophoresis

ISSN

0173-0835

e-ISSN

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Volume of the periodical

26

Issue of the periodical within the volume

9

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

1673-1679

UT code for WoS article

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EID of the result in the Scopus database

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