Plasma metallothionein levels in lead poisoned child

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F05%3A00007606" target="_blank" >RIV/62156489:43210/05:00007606 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Plasma metallothionein levels in lead poisoned child

Original language description

A 11-year-old girl was referred to the hospital by her general practitioner because of abdominal pain, vomiting, dark colour of tongue, low intake of fluid and food, and abnormal laboratory results (bilirubin 55 mmol/l, AST 2.94 mkat/l, ALT 3.46 mkat/l,haemoglobin 86 g/l). Blood film exhibited basophilic stippling, prompting for investigation of lead poisoning. Blood lead levels were measured by automated graphite furnace AAS (Varian). Plasma metallothionein levels were measured by electroanalytical technique - voltametric Brdicka reaction. In time of admission, the blood lead was 648 mg/l, and metallothionein 153 mmol/l (normal values below 10 mmol/l). Chelation therapy by EDTA was administred for five consecutive days. During the course of therapy the B-Pb decreased to 360 mg/l, U-Pb increased to 6019 mg/24h, P-metallothionein increased to 276 mmol/l. After 5 days of chelation treatment, the B-Pb increased (535 mg/l), P-metallothionen decreased (147 mmol/l). The source of 6 months l

Czech name

Množství metalothioneinu u dítěte otráveného olovem

Czech description

A 11-year-old girl was referred to the hospital by her general practitioner because of abdominal pain, vomiting, dark colour of tongue, low intake of fluid and food, and abnormal laboratory results (bilirubin 55 mmol/l, AST 2.94 mkat/l, ALT 3.46 mkat/l,haemoglobin 86 g/l). Blood film exhibited basophilic stippling, prompting for investigation of lead poisoning. Blood lead levels were measured by automated graphite furnace AAS (Varian). Plasma metallothionein levels were measured by electroanalytical technique - voltametric Brdicka reaction. In time of admission, the blood lead was 648 mg/l, and metallothionein 153 mmol/l (normal values below 10 mmol/l). Chelation therapy by EDTA was administred for five consecutive days. During the course of therapy the B-Pb decreased to 360 mg/l, U-Pb increased to 6019 mg/24h, P-metallothionein increased to 276 mmol/l. After 5 days of chelation treatment, the B-Pb increased (535 mg/l), P-metallothionen decreased (147 mmol/l). The source of 6 months l

Type

D - Article in proceedings

CEP classification

CG - Electrochemistry

OECD FORD branch

—

Project

<a href="/en/project/GP525%2F04%2FP132" target="_blank" >GP525/04/P132: Study of protection mechanisms for stress-induced by heavy metals</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Eurotox 2005; 42nd Congress of European Societes of Toxicology

ISBN

0378-4274

ISSN

—

e-ISSN

—

Number of pages

2

Pages from-to

"S156"-"S157"

Publisher name

Elsevier

Place of publication

—

Event location

—

Event date

—

Type of event by nationality

—

UT code for WoS article

—